Experimental Arsphenamine Sensitization

Post-Arsphenamine Blood Dyscrasias

Experimental Observations on the "cure" of Syphilis in the Rabbit with Arsphenamine

1. The intravenous administration of six doses of arsphenamine to syphilitic rabbits in amounts of 10 mg. per kilo, 127 days after inoculation is sufficient to render the popliteal nodes of such animals incapable of transmitting the infection to normal animals. 2. Syphilitic rabbits that have been treated in this manner and whose popliteal nodes 32 to 38 days after treatment have been shown to ...

Superinfection in Experimental Syphilis following the Administration of Subcurative Doses of Arsphenamine or Neoarsphenamine

Experiments were carried out on rabbits for the purpose of determining the effects of subcurative doses of arsphenamine and of neo-arsphenamine upon the resistance of infected animals to reinoculation with Treponema pallidum and hence the possibilities of the occurrence of a second infection in treated but uncured cases of infection. All the animals used were inoculated with the same virus, and...

Correlation between experimental human and murine skin sensitization induction thresholds.

Quantitative risk assessment for skin sensitization is directed towards the determination of levels of exposure to known sensitizing substances that will avoid the induction of contact allergy in humans. A key component of this work is the predictive identification of relative skin sensitizing potency, achieved normally by the measurement of the threshold (the "EC3" value) in the local lymph no...

Hemostatic- and fibrinolytic-affecting agents in experimental vascular sensitization.

THAT multiple alterations in hemostasis may occur during subacute hjpersensitivity reactions in the rabbit was suggested by demonstrations of physiological and histological changes during experimental procedures.^ An initial delay in blood coagulation was followed by the subsequent development of intralummal aggregates of formed elements of the blood and of thrombi in association with inflammat...